HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → 4-[4-(1-Cyclopropylcarbamoyl-ethyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 4-[4-(1-Carboxy-ethyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86686113 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[4-(1-Cyclopropylcarbamoyl-ethyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86686114 | — |
Reaction Steps
To a mixture of 3.00 g (9.00 mmol) 4-[4-(1-carboxy-ethyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester (IX.1) and 3.85 mL (22.5 mmol) DIPEA in 5 mL DMF, 4.33 g (13.5 mmol) TBTU are added. The mixture is stirred for 15 min at rt. After that time, 0.94 mL (13.5 mmol) cyclopropylamine are added and the mixture is stirred for 12 h at rt. After that time, water is added and the mixture is extracted with EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759528B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-df3e0d26be3343afa29854ba35ab927f |
| Source note | uspto-grants-2014_06 |