HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(4-Piperidin-4-yl-phenyl)-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-[4-(1-Methoxycarbonyl-ethyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86686112 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-Piperidin-4-yl-phenyl)-propionic acid methyl ester | HCID 86686117 | — |
Reaction Steps
The compound is prepared analogously to Example XI.1 using 4-[4-(1-methoxycarbonyl-ethyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester (VIII.1) as educt and TFA in DCM instead of HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759528B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-47f5e500d2944eca8497ba0406725038 |
| Source note | uspto-grants-2014_06 |