Hydrochloric Acid → HCID 57947846, compound

Participants

Reaction Steps

To a suspension of 5-(3-fluorophenyl)isoxazole-3-carbohydrazide (22.5 g, 101 mmol) in H2O (2000 mL) and HCl (2 N, 101 mL, 2.0 equiv.) at 0° C. was added a solution of sodium nitrite (13.9 g, 202 mmol, 2.0 equiv.) in H2O (100 mL). The suspension was stirred at RT for 16 h. The precipitate was filtered and washed with H2O. The solid was dried under high vacuum to give 5-(3-fluorophenyl)isoxazole-3-carbonyl azide as a yellow solid (20 g, 85%). LRMS (M+H+)m/z 179.0.

Provenance & Evidence