HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 3-Fluoro-6-trifluoromethyl-benzo[b]thiophene-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-Fluoro-6-trifluoromethyl-benzo[b]thiophene-2-carboxylic acid | HCID 59625888 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Fluoro-6-trifluoromethyl-benzo[b]thiophene-2-carbonyl chloride | HCID 59625689 | — |
Reaction Steps
To compound 15b (0.14 g, 0.53 mmol) in CH2Cl2 (5 mL) at room temperature was added (COCl)2 (0.051 mL, 0.58 mmol), followed by 2 drops of DMF. The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was then concentrated to give compound 15c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759533B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-bfba03d71a0142229485b23ba6691927 |
| Source note | uspto-grants-2014_06 |