反应详情

A solution of methyl 1H-indole-6-carboxylate 20a (11.4 mmol, 2.0 g) and N-fluoro-2,4,6-trimethylpyridinium triflate (14.8 mmol, 4.3 g) in MeOH (100 mL) was heated at reflux for 18 h. The reaction mixture was concentrated and purified by flash column chromatography (silica gel, 15-20% EtOAc/hexanes) to give compound 20b as an off-white solid.

1. temperatureat reflux for 18 h
2. concentrationThe reaction mixture was concentrated
3. custompurified by flash column chromatography (silica gel, 15-20% EtOAc/hexanes)