反应详情

温度

210 °C

A mixture of methyl 4-amino-3-hydroxy-benzoate 25a (0.3 g, 1.8 mmol) and benzoyl chloride 25b (0.23 mL, 2.0 mmol) in dioxane (2.5 mL) was heated at 210° C. under microwave for 15 min. The reaction mixture was diluted with CH2Cl2 and washed with aq. NaHCO3. The organic solution was dried over Na2SO4, concentrated and purified by flash column chromatography (silica gel, 20% EtOAc/heptane) to give 25c (0.39 g).

1. washwashed with aq. NaHCO3
2. dry with materialThe organic solution was dried over Na2SO4
3. concentrationconcentrated
4. custompurified by flash column chromatography (silica gel, 20% EtOAc/heptane)