Trifluoroacetic acid → HCID 58236615, compound

Participants

Reaction Steps

To a solution of 367 (0.074 g, 0.10 mmol) in dichloromethane (50 mL) was added trifluoroacetic acid (1.0 mL). The reaction mixture was stirred for 3 h at r.t. then concentrated and the residue was partitioned between dichloromethane and sat. NaHCO3. The organic phase was collected, washed with brine, dried over MgSO4, filtered and concentrated. The residue was purified by Gilson reverse phase HPLC (35-75% MeOH/H2O, Aquasil C18, 30 min) and lyophilized. The purified product (containing some formic acid from the HPLC) was partitioned between dichloromethane and 1M NaOH). The organic phase was collected, dried (MgSO4), filtered and concentrated to give compound 368 (0.033 g, 0.052 mmol, 52% yield).

Provenance & Evidence