Hydrochloric Acid → CNV1014802 (hydrochloride)

Participants

Reaction Steps

To a solution of E1 (72 mg, 0.23 mmol) in a mixture of ethyl acetate (1.0 ml) and methanol (1.0 ml) was added 4M HCl in 1,4-dioxane (57.5 uL, 0.23 mmol) at 0° C. The mixture was stirred for 1.5 h and slowly allowed to warm to room temperature. After evaporating the solvent, the residue was triturated with diethyl ether to afford the title compound as a white solid (75 mg, 93% yield).

Provenance & Evidence