2-Bromonaphthalene → HCID 14272583, compound

2.5 M of n-BuLi (1.9 mL/hexane, 4.83 mmol) was added to 2-bromonaphthalene (1 g, 4.83 mmol/THF (20 mL)) and reacted at −78° C. for 40 minutes under a dry and anaerobic operation condition to form a solution. SnBu3Cl (1.5 mL, 5.31 mmol) was then added to the solution and reacted at −78° C. for 1 hour. After returning to room temperature, the solution was continuously reacted for 8 hours. After the reaction was completed, the solution was extracted by ether (30 mL) and deionized water (50 mL). An organic phase was collected. After removal of ether by a rotary concentrator, the organic phase was purified by reduced-pressure distillation to form a transparent pale yellow oily product (22, 1.68 g, 83%).

1. customreacted at −78° C. for 40 minutes under
2. customa dry
3. customanaerobic operation condition to form a solution
4. customreacted at −78° C. for 1 hour
5. customAfter returning to room temperature
6. customthe solution was continuously reacted for 8 hours
7. extractionthe solution was extracted by ether (30 mL) and deionized water (50 mL)
8. customAn organic phase was collected
9. customAfter removal of ether by a rotary concentrator
10. distillationthe organic phase was purified by reduced-pressure distillation
11. customto form a transparent pale yellow oily product (22, 1.68 g, 83%)

ORD record

ord-89f9e07f340b46bdb0c6a65568de6d1c

Source dataset

uspto-grants-2014_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08759543B2