HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 67366408, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | tert-Butyl carbazate | HCID 70091 | — |
| Reactant | HCID 5426788 | HCID 5426788 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67366408 | HCID 67366408 | — |
Reaction Steps
A mixture of 4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)benzoic acid (synthesis is described in PCT/US2010/024035) (1 equiv.), EDCI (1 equiv.), and BocNHNH2 (1 equiv.), in DCM and DMF (1:1) is stirred at 25° C. overnight, followed by an aqueous/EtOAc workup. Purification if necessary by column chromatography on silica gel to give the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759548B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-87dde7bce5db42a1acdcf993178b9df2 |
| Source note | uspto-grants-2014_06 |