Hydrochloride methanol → HCID 67366697, compound

HRID 410023Notes

Reaction equation

HRID 410023 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:33])[C:7]([C:16]3[CH:32]=[CH:31][C:19]([C:20]([NH:22][NH:23]C(OC(C)(C)C)=O)=[O:21])=[CH:18][CH:17]=3)=[C:8]([C:12]([F:15])([F:14])[F:13])[O:9]2)=[CH:4][CH:3]=1.Cl.CO>>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:33])[C:7]([C:16]3[CH:32]=[CH:31][C:19]([C:20]([NH:22][NH2:23])=[O:21])=[CH:18][CH:17]=3)=[C:8]([C:12]([F:14])([F:15])[F:13])[O:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67366408HCID 67366408, compound

Product 1

HCID 67366697HCID 67366697, compound

Procedure

tert-Butyl 2-(4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)benzoyl)hydrazinecarboxylate is treated with HCl/MeOH overnight. Solvent is removed under reduced pressure to give the product.

Workup

  1. customSolvent is removed under reduced pressure
  2. customto give the product

Sources & evidence

ORD record
ord-9f7b6888234742608e9b759a707d6171
Source dataset
uspto-grants-2014_06
Patent number
US08759548B2

Reaction notes

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