反应详情

1,1′-Thiocarbonyldi-2-pyridone (4.87 g, 21 mmol) is added to a mixture of N-(3-amino-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide (5.50 g, 20 mmol) and dioxane (200 mL) and stirred at rt for 2 h and at reflux for 8 h. The mixture is concentrated, diluted with DCM and filtered over silica gel. The filtrate is concentrated to give the sub-title compound.

1. temperatureat reflux for 8 h
2. concentrationThe mixture is concentrated
3. additiondiluted with DCM
4. filtrationfiltered over silica gel
5. concentrationThe filtrate is concentrated