反应详情

温度

75 °C

N-(Hydroxymethyl)trifluoroacetamide (6.6 mmol; 0.946 g) is added to a mixture of 2,6-dichloro-nitrobenzene (0.899 mL; 6.6 mmol) and conc. H2SO4 (15 mL) at 75° C. The mixture is stirred at 75° C. overnight, poured into ice water and stirred for 1 h. The precipitate is collected by filtration and dried. Yield 0.32 g (15%). MS [M−H]−=315, HPLC-method B: Rt=1.43 min.

1. stirringstirred for 1 h
2. filtrationThe precipitate is collected by filtration
3. customdried