反应详情

A mixture of N-(3-amino-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide (0.95 g, 3.4 mmol) in 4.0 mL dioxane is added to thiophosgene (0.45 mL, 5.8 mmol) in 2.5 mL water. The mixture is stirred overnight, extracted with DCM and the organic phase is washed with 5% aq NaHCO3 solution and water and dried with Na2SO4. After filtration and concentration, the crude product is diluted with DCM, filtered through a pad of silica gel and concentrated.

1. extractionextracted with DCM
2. washthe organic phase is washed with 5% aq NaHCO3 solution and water
3. dry with materialdried with Na2SO4
4. filtrationAfter filtration and concentration
5. additionthe crude product is diluted with DCM
6. filtrationfiltered through a pad of silica gel
7. concentrationconcentrated