Ammonia → 3-Amino-4-chloro-2-fluoro-benzamide

HRID 410075Notes

Reaction equation

HRID 410075 reaction equation
[NH2:1][C:2]1[C:3]([F:12])=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5](O)=[O:6].ClC([N:18](C)C)=C(C)C.N>>[NH2:1][C:2]1[C:3]([F:12])=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5]([NH2:18])=[O:6]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 6407921-Chloro-N,N-2-trimethylpropenylamineHCID 667650743-Amino-4-chloro-2-fluorobenzoic acid

Product 1

HCID 667651113-Amino-4-chloro-2-fluoro-benzamideYield 69%

Procedure

The sub-title compound is prepared from 3-amino-4-chloro-2-fluoro-benzoic acid, (1-chloro-2-methyl-propenyl)-dimethyl-amine and conc. NH3 in analogy to step Ac.

Sources & evidence

ORD record
ord-672bd5ee070d44e3a245a8a6a5aebfd1
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

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