1,1'-Thiocarbonyldi-2(1H)-pyridone → N-(2-fluoro-4-chloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide

HRID 410078Notes

Reaction equation

HRID 410078 reaction equation
[NH2:1][C:2]1[C:3]([F:17])=[C:4]([CH:13]=[CH:14][C:15]=1[Cl:16])[CH2:5][NH:6][C:7](=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9].[C:18](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:19]>>[Cl:16][C:15]1[CH:14]=[CH:13][C:4]([CH2:5][NH:6][C:7](=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9])=[C:3]([F:17])[C:2]=1[N:1]=[C:18]=[S:19]

Participants

3

Reactant 2

HCID 8531621,1'-Thiocarbonyldi-2(1H)-pyridoneHCID 56839978N-(3-amino-4-chloro-2-fluorobenzyl)pivalamide

Product 1

HCID 56840194N-(2-fluoro-4-chloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamideYield 65%

Procedure

The title compound is prepared from N-(3-amino-4-chloro-2-fluoro-benzyl)-2,2-dimethyl-propionamide, 1,1′-thiocarbonyldi-2-pyridone in analogy to step Af.

Sources & evidence

ORD record
ord-c2bc041d8acf4577bfcaa1a15b4b6074
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

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