Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → Ethyl 4-amino-2-fluoro-5-nitrobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Ethyl 2,4-difluoro-5-nitrobenzoate | HCID 22330120 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Ethyl 4-amino-2-fluoro-5-nitrobenzoate | HCID 59529828 | — |
반응 단계
A mixture of ethyl 2,4-difluoro-5-nitro-benzoate (5.0 g, 21 mmol), 5.2 mL conc. NH3 and THF (25 mL) is stirred for 30 min in an ice bath and overnight at rt. The mixture is concentrated and diluted with water. The precipitate is filtered, washed with water and dried at 55° C. to furnish the crude sub-title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759537B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-5adf13836dd14585ac25c36bd8c0db63 |
| 출처 메모 | uspto-grants-2014_06 |