HCID 178507939, compound → HCID 178507938, compound

HRID 410089Notes

Reaction equation

HRID 410089 reaction equation
[F:1][C:2]([F:28])([F:27])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:26])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH2:20])=[CH:13][C:12]=2[O:21][CH2:22][CH:23]([F:25])[F:24])[CH2:5][CH2:4]1>[Pd]>[F:1][C:2]([F:27])([F:28])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:26])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH2:20])=[CH:13][C:12]=2[O:21][CH2:22][CH:23]([F:24])[F:25])[CH2:5][CH2:4]1

Participants

3

Reactant 1

HCID 178507939HCID 178507939, compound

Product 1

HCID 178507938HCID 178507938, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The subtitle compound is prepared from N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-amino-5-nitro-benzoic acid amide with Pd/C and H2 in analogy to example 1f.

Sources & evidence

ORD record
ord-ca678efb213d4e7e9b86fed9462c9201
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

Loading…