2-(2,2-Difluoro-ethoxy)-4-amino-5-nitro-benzoic acid → 2-(2,2-Difluoro-ethoxy)-4,5-diamino-benzoic acid

HRID 410093Notes

Reaction equation

HRID 410093 reaction equation
[F:1][CH:2]([F:18])[CH2:3][O:4][C:5]1[CH:13]=[C:12]([NH2:14])[C:11]([N+:15]([O-])=O)=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]>[Pd]>[F:1][CH:2]([F:18])[CH2:3][O:4][C:5]1[CH:13]=[C:12]([NH2:14])[C:11]([NH2:15])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]

Participants

3

Reactant 1

HCID 871396792-(2,2-Difluoro-ethoxy)-4-amino-5-nitro-benzoic acid

Product 1

HCID 871397232-(2,2-Difluoro-ethoxy)-4,5-diamino-benzoic acidYield 99%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The subtitle compound is prepared from 2-(2,2-difluoro-ethoxy)-4-amino-5-nitro-benzoic acid (example 2c) with Pd/C and H2 in analogy to example 1f.

Sources & evidence

ORD record
ord-1e353d3f3c6d43faa5000cb6fdac6d6d
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

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