HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Sulfate → Ethyl 2-(2,2-difluoroethoxy)-4-methylamino-5-amino-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate | HCID 59529798 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 2-(2,2-difluoroethoxy)-4-methylamino-5-amino-benzoate | HCID 59529827 | — |
Reaction Steps
A mixture of ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate (2.0 g; 6.57 mmol), RaNi (1.0 g) and THF (100 mL) is stirred under H2-atmosphere (8 atm) overnight at rt. Na2SO4 is added and the mixture is stirred another 30 min under H2-atmosphere. The mixture is filtered through celite and concentrated and the sub-title compound is used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759537B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-08d7e03df07a49da8cbb79d6517aa1cb |
| Source note | uspto-grants-2014_06 |