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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 410100Generated: October 28, 2026

2,2-Difluoroethan-1-ol → N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzamide

https://huagongshe.com/reaction/410100

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,2-Difluoroethan-1-olHCID 136187—
ReactantPotassium tert-butoxideHCID 23665647—
ReactantN-(4-Bromophenyl)-2-fluoro-4-methylamino-5-nitro-benzamideHCID 68052081—
ProductN-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzamideHCID 59529852—

Reaction Steps

The subtitle compound is prepared from N-(4-bromophenyl)-2-fluoro-4-methylamino-5-nitro-benzamide, 2,2-difluoroethanol and KOtBu in analogy to example 1e.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08759537B2
Source datasetuspto-grants-2014_06
ORD IDord-e13729e09b02453d8b2ae8502f41e869
Source noteuspto-grants-2014_06