HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → N-(4-Bromo-phenyl)-2-{2,6-difluoro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | N-(2,4-Difluoro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide | HCID 56840193 | — |
| Reactant | 5-amino-N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)benzamide | HCID 59529861 | — |
| Product | N-(4-Bromo-phenyl)-2-{2,6-difluoro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide | HCID 56839973 | — |
Reaction Steps
The title compound is prepared from N-(4-bromophenyl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzamide and N-(2,4-difluoro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide with DIC in analogy to example 1g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759537B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-66e56a629ed34b0bb6bf0dc0bce8ae35 |
| Source note | uspto-grants-2014_06 |