N-(4-Bromophenyl)-2-fluoro-4-methylamino-5-nitro-benzamide → N-(4-bromophenyl)-2-fluoro-4-methylamino-5-amino-benzamide

HRID 410103Notes

Reaction equation

HRID 410103 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:22])[C:10]2[CH:15]=[C:14]([N+:16]([O-])=O)[C:13]([NH:19][CH3:20])=[CH:12][C:11]=2[F:21])=[CH:4][CH:3]=1>[Ni]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:22])[C:10]2[CH:15]=[C:14]([NH2:16])[C:13]([NH:19][CH3:20])=[CH:12][C:11]=2[F:21])=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 68052081N-(4-Bromophenyl)-2-fluoro-4-methylamino-5-nitro-benzamide

Product 1

HCID 68052072N-(4-bromophenyl)-2-fluoro-4-methylamino-5-amino-benzamide

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

The subtitle compound is prepared from N-(4-bromophenyl)-2-fluoro-4-methylamino-5-nitro-benzamide, RaNi and H2 in analogy to example 5c.

Sources & evidence

ORD record
ord-c050d5d1feea4b8ba5951bd990a05241
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

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