Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromoaniline → N-(4-Bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-amino-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromoaniline | HCID 7807 | — |
| 반응물 | Cyclopropylamine | HCID 69828 | — |
| 반응물 | 2,2-Difluoroethan-1-ol | HCID 136187 | — |
| 반응물 | 2,4-Difluoro-5-nitrobenzoic acid | HCID 2782822 | — |
| 반응물 | N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-nitro-benzamide | HCID 86669633 | — |
| 촉매 | HCID 178506447 | HCID 178506447 | — |
| 생성물 | N-(4-Bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-amino-benzamide | HCID 86669632 | — |
반응 단계
The subtitle compound is prepared from N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-nitro-benzamide (prepared from 2,4-difluoro-5-nitrobenzoic acid, cyclopropylamine, 4-bromoaniline and 2,2-difluoroethanol in analogy to the examples 1c, 6a, 1e) and RaNi/H2 in analogy to example 5c.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759537B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-82de4134b99642ad9588ec0d3469cb1c |
| 출처 메모 | uspto-grants-2014_06 |