HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-fluoroaniline → N-(4-Fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-amino-benzoic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| Reactant | 2-Fluoro-4-(methylamino)-5-nitrobenzoic acid | HCID 59529834 | — |
| Reactant | N-(4-Fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide | HCID 67957648 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | N-(4-Fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-amino-benzoic acid amide | HCID 68052224 | — |
Reaction Steps
The subtitle compound is prepared from N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide (prepared from 2-fluoro-4-methylamino-5-nitro-benzoic acid, 4-fluoro-3-chloro-aniline in analogy to the step 6a) with RaNi and H2 in analogy to example 5c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759537B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-ceffd051565744838254188dc4a6cfaf |
| Source note | uspto-grants-2014_06 |