Iodine → Thyroxine

Participants

Reaction Steps

FIG. 2: Preparation of the disodium salt of L-thyroxine (compound of Formula II) i.e. according to IT1302201 by iodination of compound of Formula I with KI/I2 in the presence of a suitable amine. The mono and di-potassium salts mixture is subjected to a subsequent separation and purification steps, including:(a) the addition of an organic acid; (b) the separation of the thus obtained “free form” (as a precipitate); and (c) the addition of an excess of sodium hydroxide to obtain the L-thyroxine di-sodium salt of Formula II.

Provenance & Evidence