HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 410154Generated: November 1, 2026
Ethylparaben → Ethyl 4-(3-(trifluoromethyl)pyridin-2-yloxy)benzoate
https://huagongshe.com/reaction/410154
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylparaben | HCID 8434 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Fluoro-3-(trifluoromethyl)pyridine | HCID 2783296 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 4-(3-(trifluoromethyl)pyridin-2-yloxy)benzoate | HCID 59326875 | — |
Reaction Steps
Fluoro-3-(trifluoromethyl)pyridine (848 mg, 5137 μmol), cesium carbonate (2008 mg, 6164 μmol) and ethyl 4-hydroxybenzoate (854 mg, 5137 μmol) were combined in DMSO (12 mL) and heated to 80° C. overnight. After complete disappearance of starting material, the mixture was cooled to RT and diluted with water and extracted with ethyl acetate. The combined organics were washed with brine, dried over Na2SO4, filtered and concentrated to give the desired product which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08759532B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-13b06cb5e2604c3899dfecbd82f9429d |
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| Source note | uspto-grants-2014_06 |
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