HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 410182Generated: October 25, 2026
2-Chlorobenzimidazole → N-(4-(3-methylpyridin-2-yloxy)phenyl)-1H-benzo[d]imidazol-2-amine
https://huagongshe.com/reaction/410182
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chlorobenzimidazole | HCID 78572 | — |
| Reactant | 4-[(3-methyl-2-pyridinyl)oxy]Benzenamine | HCID 59326808 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-(4-(3-methylpyridin-2-yloxy)phenyl)-1H-benzo[d]imidazol-2-amine | HCID 59327050 | — |
Reaction Steps
A mixture of 4-(3-methylpyridin-2-yloxy)benzenamine (1.00 g, 4.99 mmol) and 2-chlorobenzimidazole (0.860 g, 5.64 mmol) in 10 mL of iPrOH was heated at 170° C. for 30 min in the microwave. The reaction mixture was evaporated onto silica gel. Purification by flash chromatography (2M NH3 in MeOH:CH2Cl2) afforded N-(4-(3-methylpyridin-2-yloxy)phenyl)-1H-benzo[d]imidazol-2-amine as solid. MS (ESI, pos. ion) m/z: 317.1 (M+1). IC50 (uM) ++++.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08759532B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-739bd55979864d75a23d6495f47030de |
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| Source note | uspto-grants-2014_06 |
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