HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cesium carbonate → 2-(4-(1-Methyl-1H-benzo[D]imidazol-2-ylamino)phenoxy)nicotinaldehyde
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | 2-Chloro-3-pyridinecarboxaldehyde | HCID 737607 | — |
| Edukt | 4-(1-methyl-1H-benzoimidazol-2-ylamino)-phenol | HCID 59327014 | — |
| Lösungsmittel | Dimethyl Sulfoxide | HCID 679 | — |
| Produkt | 2-(4-(1-Methyl-1H-benzo[D]imidazol-2-ylamino)phenoxy)nicotinaldehyde | HCID 59327252 | — |
Reaktionsschritte
A solution of 2-chloropyridine-3-carboxaldehyde (3 g, 21 mmol), 4-(1-methyl-1H-benzo[d]imidazol-2-ylamino)phenol (5 g, 21 mmol), CESIUM CARBONATE (10 g, 32 mmol) in DMSO (60 mL) was heated to 80° C. overnight. Purification by aqueous workup (water, brine) and DCM extraction then Biotage (0-10% DCM/MeOH) produced product which partially solidified.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08759532B2 |
| Quelldatensatz | uspto-grants-2014_06 |
| ORD ID | ord-7a1b96e1b00d4beebf739f6685a9bf5c |
| Quellennotiz | uspto-grants-2014_06 |