HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 410227Generated: November 3, 2026
Cesium carbonate → HCID 59326885, compound
https://huagongshe.com/reaction/410227
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 59326778 | HCID 59326778 | — |
| Reactant | (1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone | HCID 59326874 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 59326885 | HCID 59326885 | — |
Reaction Steps
To a solution of 3-(4-(difluoromethyl)tetrahydro-2H-pyran-4-yl)-2-fluoropyridine (0.1 g, 0.432 mmol) in NMP was added cesium carbonate (0.282 g, 0.865 mmol) and (1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone (0.155 g, 0.649 mmol). The resulting mixture was heated to 175° C. overnight. Purification by prep-plate TLC (5% MeOH/DCM & 75% EtOAc/hexane) produced product. MS (ESI, pos. ion) m/z: 450 (M+1). IC50 (uM) +++++.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08759532B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-450784434113473a90e1ace4ac38159b |
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| Source note | uspto-grants-2014_06 |
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