反应详情

温度

80 °C

To a sealable vessel was added 4-(tert-butyldimethylsilyloxy)cyclohex-1-enyl trifluoromethanesulfonate (1.90 g, 5.27 mmol), sodium carbonate as a 2N solution in water (7.91 mL, 15.81 mmol), and 2-fluoropyridin-3-ylboronic acid (0.891 g, 6.33 mmol) before adding tetrakis(triphenylphosphine)palladium(0) (0.305 g, 0.264 mmol) under argon. The reaction mixture was sealed and set stirring at 80° C. After complete consumption of starting material, the black mixture was diluted with water before extracting with dichloromethane, drying over sodium sulfate, filtering, and concentrating under reduced pressure to an orange oil, which was used without purification. MS (ESI, pos. ion) m/z: 308.0 (M+1).

1. customThe reaction mixture was sealed
2. customAfter complete consumption of starting material
3. additionthe black mixture was diluted with water
4. extractionbefore extracting with dichloromethane
5. dry with materialdrying over sodium sulfate
6. filtrationfiltering
7. concentrationconcentrating under reduced pressure to an orange oil, which
8. customwas used without purification