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HRID41028

反应详情

EQUATION

反应方程式

HRID 41028 的结构方程式

REACTANTS

反应物

2
结构：O=C=NCCBr
HCID4255957

未命名化合物

结构：COC(=O)C1(C)Cc2c([nH]c3ccc(OC)cc23)C(c2cccc(O)c2)N1
HCID68851536

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2[nH]c3c(c2c1)CC1(C)C(=O)N(CCBr)C(=O)N1C3c1cccc(O)c1
HCID68939448

未命名化合物

收率 74%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCC(C)=O
溶剂HCID6569

Methyl ethyl ketone

C4H8O

PROCEDURE

实验过程

To a solution of 3.17 g (1RS,3SR)-1-(3-Hydroxy-phenyl)-6-methoxy-3-methyl-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid methyl ester in 35 ml 2-butanon are added 860 μl bromoethyl isocyanate. The mixture is heated to reflux for 7 h and is stirred at room temperature over night. The precipitated compound is filtered and washed with 2-butanon. 3.09 g (74%) of the title compound are obtained. m.p.: 299-302° C., MS: m/z (MH+)=484.0/486.0

WORKUP

后处理

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 7 h
  3. filtrationThe precipitated compound is filtered
  4. washwashed with 2-butanon