Hydrochloric Acid → HCID 59327161, compound

Participants

Reaction Steps

After 2 h, more (trifluoromethyl)trimethylsilane (1.906 g, 13.40 mmol) and tetra-n-butylammonium fluoride, 1.0M in THF (0.536 mL, 0.536 mmol) were added. After a total of 4 h, 10% hydrochloric acid solution (50 ml) was added, and the reaction was stirred for 15 min. The solution was diluted with EtOAc (200 ml) and washed with 10% hydrochloric acid solution (50 ml), water (50 ml) and brine (50 ml), dried over MgSO4, concentrated in vacuo and purified by silica gel chromatography (eluant: 10-45% EtOAc/hexane), affording the product as a yellow oil. MS (ESI, pos. ion) m/z: 248.0 (M+1).

Provenance & Evidence