Ethanol → HCID 59327218, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of (1H-benzo[d]imidazol-2-yl)(4-(3-bromopyridin-2-yloxy)phenyl)methanone. (17.0 g, 43.1 mmol) in ethanol (600 mL) was added dppf (0.716 g, 1.29 mmol) and Pd(OAc)2 (77 mg, 0.344 mmol) and sodium acetate (14.13 g, 172 mmol) in 2.0 L. autoclave and apply CO(g) 15 kg/cm2 pressure. Then the reaction mixture was heated up to 135° C. and maintained at that temperature for 1 h. The reaction mass was concentrated under vacuum and diluted with water, then extracted by ethyl acetate (3×500 mL). The combined organic extracts were dried over sodium sulfate and concentrate under vacuum to give the title compound as dark brown solid. MS (ESI, pos. ion) m/z: 389.1 (M+1).

Provenance & Evidence