HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethylamine → HCID 59326842, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 59326812 | HCID 59326812 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59326842 | HCID 59326842 | — |
Reaction Steps
HATU (122 mg, 0.321 mmol) was added to a mixture of 2-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)nicotinic acid (105 mg, 0.292 mmol) and diisopropylethylamine (102 μL, 0.584 mmol) in DMF (1 mL) and the mixture was stirred at RT for 10 min. 2-Phenethylamine (55.4 μL, 0.438 mmol) was added, and the mixture was stirred at RT for 1 h. The mixture was purified by chromatography on silica gel to deliver 2-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)-N-phenethylnicotinamide as an off-white solid. MS (ESI, pos. ion) m/z: 463.1 (M+1). IC50 (uM) +.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759532B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-655075fc6475430497c72cb71ef3bd8b |
| Source note | uspto-grants-2014_06 |