Benzene, 2-fluoro-4-methyl-1-nitro- → HCID 67422183, compound

Participants

Reaction Steps

To a solution of 3-fluoro-4-nitrotoluene (0.30 g, 1.93 mmol) in EtOH (18 ml) at rt under nitrogen was added 4-bromobenzylamine (0.36 g, 1.93 mmol) slowly. The reaction was warmed to reflux where it was maintained for 2 d. After this time, the mixture was cooled to rt and concentrated under reduced pressure. The crude product was partitioned between H2O and EtOAc and the organic phase was separated, washed with 5N HCl, dried (Na2SO4) and concentrated under reduced pressure to provide (4-bromo-benzyl)-(5-methyl-2-nitro-phenyl)-amine (0.45 g, 72%) as a yellow solid.

Provenance & Evidence