HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → (3aSR,10RS)-6-Ethoxy-10-(3-hydroxy-phenyl)-3a-methyl-2-(2-methylamino-ethyl)-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | (3aSR,10RS)-2-(2-Bromo-ethyl)-6-ethoxy-10-(3-hydroxy-phenyl)-3a-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione | HCID 68937590 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (3aSR,10RS)-6-Ethoxy-10-(3-hydroxy-phenyl)-3a-methyl-2-(2-methylamino-ethyl)-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione | HCID 68942580 | — |
Reaction Steps
The title compound is prepared similarly as described for example 29 using (3aSR,10RS)-2-(2-Bromoethyl)-6-ethoxy-10-(3-hydroxy-phenyl)-3a-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]-fluorene-1,3-dione (example 22) and a 2 M solution of methyl amine in tetrahydrofurane instead of azetidine as starting materials. MS: m/z (MH+)=449.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530493B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-d05d684d536149239802b757cebea126 |
| Source note | uspto-grants-2013_09 |