HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → (3aSR,10RS)-6-(1,1-Difluoro-methoxy)-10-(3-hydroxy-phenyl)-3a-methyl-2-(2-methylaminoethyl)-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | (3aSR,10RS)-2-(2-Bromoethyl)-6-(1,1-difluoro-methoxy)-10-(3-hydroxy-phenyl)-3a-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione | HCID 68939720 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (3aSR,10RS)-6-(1,1-Difluoro-methoxy)-10-(3-hydroxy-phenyl)-3a-methyl-2-(2-methylaminoethyl)-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione | HCID 68944341 | — |
Reaction Steps
The title compound is prepared similarly as described for example 30 using (3aSR,10RS)-2-(2-Bromoethyl)-6-(1,1-difluoro-methoxy)-10-(3-hydroxy-phenyl)-3a-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione (example 36) and a 2 M solution of methyl amine in tetrahydrofurane as starting materials. MS: m/z (MH+)=471.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530493B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-4df33085db5747238d92d8c10eab8b8a |
| Source note | uspto-grants-2013_09 |