Dimethylformamide → HCID 67430246, compound

Participants

Reaction Steps

Sodium hydride (60% dispersion in mineral oil) (47.0 mg, 1.175 mmol) was added to a 0° C. solution of Intermediate 1 (250 mg, 1.068 mmol) in DMF (3 mL) and THF (3 mL) and the mixture was allowed to react for 1 hour. Methyl iodide (0.080 ml, 1.281 mmol) was added and the mixture further reacted for 2 hours. The reaction mixture was poured in dilute aqueous NH4Cl and extracted twice with diethyl ether. The organic fraction was concentrated and the residue was passed through a plug of silica eluting with 1:10 ethyl acetate:hexane to yield 2-bromo-5-(1-methoxycyclobutyl)-1,3-thiazole (225 mg, 85%). 1H NMR (500 MHz, (CD3)2CO): δ 7.73 (s, 1H); 3.19 (s, 3H); 2.54-2.40 (m, 4H); 1.92-1.82 (m, 2H).

Provenance & Evidence