Dimethylformamide → Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)-4-hydroxycyclohexanecarboxylate

HRID 410441Notes

Reaction equation

HRID 410441 reaction equation
[OH:1][C:2]1([C:15]2[S:16][CH:17]=[CH:18][N:19]=2)[CH2:7][CH2:6][CH:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.CN(C=O)C.C1C(=O)N([Br:32])C(=O)C1>O.C(OCC)(=O)C>[Br:32][C:17]1[S:16][C:15]([C:2]2([OH:1])[CH2:7][CH2:6][CH:5]([C:8]([O:10][C:11]([CH3:14])([CH3:12])[CH3:13])=[O:9])[CH2:4][CH2:3]2)=[N:19][CH:18]=1

Participants

6

Reactant 3

HCID 6228DimethylformamideHCID 67184N-bromobutanimideHCID 67257275Tert-butyl 4-hydroxy-4-(1,3-thiazol-2-yl)cyclohexanecarboxylate

Product 1

HCID 70926225Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)-4-hydroxycyclohexanecarboxylateYield 79.7%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a flask containing the product of Step 1 (9.25 g, 33 mmol) was added DMF (36 mL) and then n-bromosuccinimide (6.97 g, 32 mmol). The reaction was allowed to stir until complete by LCMS. The reaction was diluted with water and ethyl acetate. The organic layer was separated, dried over magnesium sulfate, filtered and concentrated. Flash chromatography was used for purification to yield tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)-4-hydroxycyclohexane-carboxylate (9.24 g, 25.5 mmol, 78% yield). MS ESI: [M+H]+ m/z 364.0.

Workup

  1. customThe organic layer was separated
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customFlash chromatography was used for purification

Sources & evidence

ORD record
ord-eb8bacb1ab1d409c9bd1666e54744606
Source dataset
uspto-grants-2014_06
Patent number
US08759366B2

Reaction notes

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