Propane, 1-chloro-3-isocyanato- → (3aSR,10RS)-2-(3-Chloro-propyl)-10-(3-hydroxy-phenyl)-6-methoxy-3a-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione

Participants

Role	Name	HCID	Charge
Reactant	Propane, 1-chloro-3-isocyanato-	HCID 166752	—
Reactant	(1RS,3RS)-1-(3-hydroxy-phenyl)-6-methoxy-3-methyl-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid methyl ester	HCID 68851536	—
Product	(3aSR,10RS)-2-(3-Chloro-propyl)-10-(3-hydroxy-phenyl)-6-methoxy-3a-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione	HCID 68945212	—

Reaction Steps

The title compound is prepared analogously to the procedure described for example 22, using chloro propyl isocyanate and (1RS,3SR)-1-(3-hydroxy-phenyl)-6-methoxy-3-methyl-2,3,4,9-tetrahydro-1H-betacarboline-3-carboxylic acid methyl ester. MS: m/z (MH+)=454.0

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08530493B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-93b0e5b91886438e8a8a12fb77959a38
Source note	uspto-grants-2013_09