HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 2-Fluoro-4-(methylamino)-5-nitrobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Methyl 2,4-difluoro-5-nitrobenzoate | HCID 11447263 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Fluoro-4-(methylamino)-5-nitrobenzoic acid | HCID 59529834 | — |
Reaction Steps
2-Fluoro-4-methylamino-5-nitro-benzoic acid (375 mg) was prepared by following General Procedure A starting from 2,4-difluoro-5-nitro-benzoic acid methyl ester (440 mg) and methylamine (2 M in THF, 1.01 mL) in DMF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759535B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-7aa031a8a9804614875f056be1e8c806 |
| Source note | uspto-grants-2014_06 |