Methyl 2-methoxy-4-(methylamino)-5-nitrobenzoate → HCID 67230618, compound

HRID 410785Notes

Reaction equation

HRID 410785 reaction equation
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[O:15][CH3:16]>[Pd]>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[O:15][CH3:16]

Participants

3

Reactant 1

HCID 67331452Methyl 2-methoxy-4-(methylamino)-5-nitrobenzoate

Product 1

HCID 67230618HCID 67230618, compoundYield 90.5%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

5-Amino-2-methoxy-4-methylamino-benzoic acid methyl ester (95 mg) was prepared by following General Procedure B starting from 2-methoxy-4-methylamino-5-nitro-benzoic acid methyl ester (120 mg) and Pd/C (10% by weight, 12 mg). The crude product was used in the next step without further purification.

Workup

  1. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-40e9d648debf4a0f8e81990b093d3c41
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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