HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(ethylamino)-3-nitrobenzoate → Methyl 3-amino-4-(ethylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(ethylamino)-3-nitrobenzoate | HCID 20626654 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | Methyl 3-amino-4-(ethylamino)benzoate | HCID 12758354 | 92.3% |
Reaction Steps
3-Amino-4-ethylamino-benzoic acid methyl ester (3.2 g) was prepared by following General Procedure B starting from 4-ethylamino-3-nitro-benzoic acid methyl ester (4.0 g) and Pd/C (20% by weight, 800.0 mg) in MeOH:EtOAc (1:1, 30.0 mL). The crude product was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759535B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-23c12701737f48caa52d7b79af07e896 |
| Source note | uspto-grants-2014_06 |