HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-((2-methoxyethyl)amino)-3-nitrobenzoate → Methyl 3-amino-4-[(2-methoxyethyl)amino]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-((2-methoxyethyl)amino)-3-nitrobenzoate | HCID 67335214 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | Methyl 3-amino-4-[(2-methoxyethyl)amino]benzoate | HCID 50742440 | 94.5% |
Reaction Steps
3-Amino-4-(2-methoxy-ethylamino)-benzoic acid methyl ester (800.0 mg) was prepared by following General Procedure B starting from 4-(2-methoxy-ethylamino)-3-nitro-benzoic acid methyl ester (960.0 mg) and Pd/C (20% by weight, 190.0 mg) in MeOH:EtOAc (1:1, 10.0 mL). The crude product was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759535B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-9041e3f6b2594ed994089263f2040a94 |
| Source note | uspto-grants-2014_06 |