HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine hydrochloride → Methyl 4-(ethylamino)-3-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine hydrochloride | HCID 11198 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methyl 4-chloro-3-nitrobenzoate | HCID 735797 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 4-(ethylamino)-3-nitrobenzoate | HCID 20626654 | — |
Reaction Steps
4-Ethylamino-3-nitro-benzoic acid methyl ester (8.3 g) was prepared by following General Procedure A starting from methyl 4-chloro-3-nitrobenzoate (10.0 g), DIEA (1.6 mL) and ethylamine hydrochloride salt (4.5 g) in DMF (50.0 mL). The crude product was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759535B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-6437faa395dd474ebbba6e20fb4eced7 |
| Source note | uspto-grants-2014_06 |