huagongshe.com
HRID410918

反应详情

EQUATION

反应方程式

HRID 410918 的结构方程式

REACTANTS

反应物

4
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：Nc1nc2ccc(Cl)cc2s1
HCID7226

2-Benzothiazolamine, 6-chloro-

C7H5ClN2S

结构：S=C(n1ccnc1)n1ccnc1
HCID80264

Thiocarbonyldiimidazole

C7H6N4S

结构：CCNc1ccc(C(=O)OC)cc1N
HCID12758354

Methyl 3-amino-4-(ethylamino)benzoate

C10H14N2O2

PRODUCTS

生成物

1
结构：CCn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)OC)ccc21
HCID86656858

未命名化合物

收率 44.2%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

2-(6-Chloro-benzothiazol-2-ylamino)-1-ethyl-1H-benzoimidazole-5-carboxylic acid methyl ester (926.0 mg) was prepared by following General Procedure D starting from 3-amino-4-ethylamino-benzoic acid methyl ester (1.06 g), 2-amino-6-chloro-benzothiazole (1.0 g), 1,1′-thiocarbonyldiimidazole (979.0 mg), and EDC (1.05 g) in DMF (5.0 mL).