HuagongsheHuagongshe Chemistry Print Report · For research reference only
Riluzole → HCID 58397824, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Riluzole | HCID 5070 | — |
| Reactant | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| Reactant | 1-[3-Amino-4-(methylamino)phenyl]ethan-1-one | HCID 2779769 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 58397824 | HCID 58397824 | 68.8% |
Reaction Steps
1-[1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazol-5-yl]-ethanone (69 mg) was prepared by following General Procedure D starting from 1-(3-amino-4-methylamino-phenyl)-ethanone (41 mg), 2-amino-6-(trifluoromethoxy)-benzothiazole (59 mg), 1,1′-thiocarbonyldiimidazole (44 mg), and EDC (48 mg). LC/MS: m/z 408.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759535B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-3154ff0b848041b9a373afa573323f65 |
| Source note | uspto-grants-2014_06 |