HCID 67333354, compound → HCID 67332947, compound

HRID 410959Notes

Reaction equation

HRID 410959 reaction equation
[CH3:1][NH:2][C:3]1[CH:4]=[C:5]([CH2:12][C:13]([NH2:15])=[O:14])[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>CO.CCOC(C)=O.[Pd]>[NH2:9][C:8]1[CH:7]=[CH:6][C:5]([CH2:12][C:13]([NH2:15])=[O:14])=[CH:4][C:3]=1[NH:2][CH3:1]

Participants

4

Reactant 1

HCID 67333354HCID 67333354, compound

Product 1

HCID 67332947HCID 67332947, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

2-(4-Amino-3-methylamino-phenyl)-acetamide (554 mg) was prepared by following General Procedure B beginning with 2-(3-methylamino-4-nitro-phenyl)-acetamide (727.0 mg) and Pd/C (20% by weight, 140.0 mg) in MeOH:EtOAc (1:1, 10.0 mL). The crude product was used in the next step without further purification.

Workup

  1. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-2e542e1202a349398ecf85aebc979c50
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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