HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diglycolamine → HCID 86656889, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diglycolamine | HCID 13578 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 86656890 | HCID 86656890 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86656889 | HCID 86656889 | 42.9% |
Reaction Steps
(2-{2-(6-Chloro-benzothiazol-2-ylamino)-5-[2-(2-hydroxy-ethoxy)-ethylcarbamoyl]-benzoimidazol-1-yl}-ethyl)-methyl-carbamic acid tert-butyl ester (73 mg) was prepared by following General Procedure F starting from 1-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-2-(6-chloro-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid (145 mg), 2-(2-amino-ethoxy)-ethanol (35 mg), HBTU (125 mg), and DIEA (100 uL) in DMF (1 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759535B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-f5f414c6ada94fd19d5afff807baeb6b |
| Source note | uspto-grants-2014_06 |